Frank Reynolds often carries around a gun, a Smith & Wesson Model 19 Snubnose, which he pulls out and waves around at regular intervals. Whenever he pulls it out, someone or something is shot (usually) repeatedly.
- The first appearance of Frank's gun is used in a game of Russian Roulette in the basement of Paddy's Pub in Frank's "anything goes" gambling parlor. A shot is fired off screen, presumably killing one of the Roulette contestants, prompting Dennis and Mac to call the police. ("Charlie Goes America All Over Everybody's Ass")
- Frank fires his pistol at the ceiling several times in Charlie's apartment, while frustrated that he can't find Bruce Mathis's address via Myspace. Frank pulls the trigger at the computer several times then finally fires a shot left in the cylinder in the air. ("Dennis and Dee Get a New Dad")
- Frank accidentally shot Doyle McPoyle in the leg while tripping on acid (while laying on the ground). ("The Gang Gets Invincible")
- Mac tossed Frank his gun when he's in the vents. ("The Gang Gets Held Hostage")
- Frank pulled the gun when Charlie was threatening to choke him to death in Charlie's "bad room". ("The Gang Gets Held Hostage")
- Frank fired his gun on the roof in a one-sided shootout with the McPoyles. He missed every shot. ("The Gang Gets Held Hostage")
- Mac asked Frank to get his gun and convince Mr. Kim to shut down the Korean bar down the street. He almost fires the gun to open the door marked Private, but Mr. Kim opens the door and he hides the gun. ("The Gang Solves the North Korea Situation")
- Frank gives a "one gun salute" at Charlie and Mac's funeral (much to the displeasure of Dee), succeeding in waking up Mac's mom. ("Mac and Charlie Die (Part 2)")
- Franklin and Charles, the 1776 equivalents of Frank and Charlie, steal some guns that they plan to sell, but the guns fail after they are "cursed" by Deandra, who is a witch. Unfortunately for the two of them, one of the guns does fire later -- and blows off the head of Col. Cricket, the commander of the British troops stationed in Philadelphia. ("The Gang Cracks the Liberty Bell")
- Frank pulls his gun on the "Juarez" family after the mother stabs him in the leg, apparently feeling that him approaching them with a pair of scissors yelling "¡Corta! ¡Corta!" ("Cut! Cut") was a threatening guesture. I can't imagine why they'd come to that conclusion. ("The Gang Gets Extreme: Home Makeover Edition")
- Frank waves his gun around as he enters the bar, after being told there's a grease fire at Paddy's. In reality, the Gang has tricked him into the bar to give Frank an intervention. Earlier in the episode, Charlie, Dennis, and Dee warn a therapist that they are thinking of hiring to run the intervention that Frank will be armed, and they suggest that she be armed too. ("The Gang Gives Frank an Intervention")
- Frank turns his gun into a watergun that can deliver a "shot" of alcohol, calling it the Gun Shot. ("Paddy's Pub: Home of the Original Kitten Mittens")
- After a car accident strands The Gang in the woods of New Jersey, Frank pulls his gun on a rabbit, preparing to shoot it for food. But when the rabbit seems to be staring right at him, Frank decides they are "having a moment", and that the rabbit "has his soul", so Frank cannot shoot the rabbit. ("The Gang Gets Stranded in the Woods")
- Frank uses his gun as a prop in the climatic scene of "Lethal Weapon 5", as his character, Chief Lazarus, reveals to Riggs and Murtaugh that he had a gun hidden on him. Earlier in the scene, he had been seen firing a TEC-9 at them. ("Dee Reynolds: Shaping America's Youth")
- When the power goes out at Paddy's before the "storm of the century" hits, Frank pulls his gun to defend Paddy's from "looters" -- and he then proceeds to shoot Rickety Cricket, who was hiding out in the "Y2K bunker" in the basement of Paddy's, in the hand. ("The Storm of the Century") This marks the only time (so far) that Frank has actuallly shot someone with the gun.
- Frank's brother Gino Reynolds introduces him to guns in the 1960's. ("Frank's Brother")
- Frank keeps a city official he is trying to bribe into giving him the contract to collect trash for the city (who had previously been seen as the executive trying to buy Paddy's in the episode "The Gang Sells Out") at the gay strip club he and Dee have taken him to by holding his gun on him (thus avoiding having him just slip out like he did before.) ("The Gang Recycles Their Trash")
- Dee tells her therapist that Frank pulled out his gun during a disastrous dinner party that she had for The Gang at her therapist's suggestion. ("The Gang Gets Analyzed")
- Frank becomes a strong advocate of gun ownership, going on Philadelphia TV and radio to encourage people to buy as many guns as they can. He also reveals that he has purchased a second gun to complement the one he usually carries. ("Gun Fever Too: Still Hot")
- Frank shows up at Paddy's wielding his gun, determined to stop Psycho Pete before he kills them all. However, Psycho Pete then tells The Gang that he was not committed to a mental institution for killing his family, as they believed (actually a rumor they started), but for social anxiety disorder and depression. ("Psycho Pete Returns")
- Frank takes Bill Ponderosa's gun away from him to stop Bill from shooting himself. He's later knocked out by an irate father, who was helping to kick Bill's ass after he was caught getting a hand job from an apparently underage girl. He's stuffed in the trunk of Bill's car, and when he wakes up, he uses the gun to shoot his way out of the trunk. ("Being Frank")
- Frank brings his gun along for his ride aboard Paddy's Wagon, the Gang's attempt at a "mobile bar", as protection "if anyone gets out of line." Dennis takes it away. ("Charlie Catches a Leprechaun")
The other members of The Gang have also had guns at various points in the series:
- In the episode "Gun Fever" (which preceded Danny DeVito joining the cast), The Gang buys a gun for the bar, which all of them shoot at various points.
- In the episode "The Gang Gets Whacked (Part 2)", Dee and Charlie, who have become coke dealers (with Rickety Cricket's help), buy guns, which they, along with Frank, pull when the mob comes to collect the money they are owed for their coke.
- In "Mac and Charlie Die (Part 1)", as part of their plan to fake their deaths, Charlie and Mac buy a gun at a pawn shop, which Mac tries to use to blow up Dee's car by shooting the gas tank, which fails.
- In "The Waitress is Getting Married", Mac is seen loading a gun, as he and Dennis prepare to defend themselves if the news that The Waitress is engaged to another man causes Charlie to snap.
- In the episode "Paddy's Pub: Home of the Original Kitten Mittens", Mac and Dennis convert a shotgun to blast shots of tequila.
- In the epsiode "Gun Fever Too: Still Hot", Charlie carries a gun to help protect a school (which he pulls on both the principal of the school, and at least one student.) Dennis and Dee, in an effort to prove that it is too easy to get guns, try to buy an assault rifle, but various mishaps, and their shady pasts, prevent them from doing that.
- Charlie: And you know what? If we're taking that approach, you might wanna be armed at this intervention.
- Tabitha: Why- Why would I need to be armed?
- Charlie: Well, Frank's usually carrying a little gun with him. And he doesn't really hesitate to use it.
- Frank: A gun! I love guns! I got a gun of my own!..
- Season Two: Charlie Goes America All Over Everybody's Ass, Dennis and Dee Get a New Dad
- Season Three: The Gang Gets Invincible, The Gang Gets Held Hostage, The Gang Solves the North Korea Situation, The Gang Gets Whacked (Part 2)
- Season Four: Mac and Charlie Die (Part 2)
- Season Five: The Gang Gives Frank an Intervention, Paddy's Pub: Home of the Original Kitten Mittens, A Very Sunny Christmas (mentioned only)
- Season Six: Lethal Weapon 5 episode, The Gang Gets Stranded in the Woods
- Season Seven: The Storm of the Century
- Season Eight: The Gang Recycles Their Trash, The Gang Gets Analyzed (mentioned only)
- Season Nine: Gun Fever Too: Still Hot
- Season Ten: Psycho Pete Returns
- Season Eleven: Charlie Catches a Leprechaun